Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.61 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18973052 | 0.87 | BDKRB2 (0.73) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL20187115 | 0.86 | BDKRB2 (0.59) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL20187024 | 0.86 | MEN1 (0.63) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL20340403 | 0.85 | BDKRB2 (0.57) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL5100454 | 0.84 | BDKRB2 (0.55) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7995842 | 0.83 | CYP2D6 (0.80) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL7759170 | 0.83 | MEN1 (0.77) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL18972830 | 0.83 | BDKRB2 (0.55) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| SCHEMBL10736163 | 0.82 | OPRL1 (0.59) | MEN1CYP3A4CYP2D6CYP2C9KMT2A | |
| Hydrochloric Acid SCHEMBL17140435 | 0.82 | BDKRB2 (0.54) | MEN1CYP3A4CYP2D6CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317279-B1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-06-06 | — | — | US | disclosed |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMAN LA-ROCHE INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA-ROCHE INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | MEN1 1263/4885CYP3A4 4259/4885CYP2D6 3278/4885 |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | MEN1 1263/4885CYP3A4 4259/4885CYP2D6 3278/4885 |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | MEN1 1263/4885CYP3A4 4259/4885CYP2D6 3278/4885 |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | MEN1 1263/4885CYP3A4 4259/4885CYP2D6 3278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.