Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.73 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.73 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021165 | 0.86 | HDAC1 (0.78) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL675474 | 0.84 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL676080 | 0.84 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL676079 | 0.84 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL2021264 | 0.82 | HDAC1 (0.85) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL674669 | 0.79 | NPC1 (0.86) | HDAC1HDAC6HDAC8HDAC3HDAC11 | |
| SCHEMBL28610713 | 0.78 | CA1 (0.77) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL942259 | 0.76 | CA1 (1.00) | HDAC1HDAC6HDAC8HDAC2CA1 | |
| SCHEMBL22077754 | 0.75 | POLB (0.47) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL22111715 | 0.75 | POLB (0.47) | HDAC1HDAC6HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221773-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | claimed |
| US-20130045982-A1 | BENZAMIDE DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2013-02-21 | — | — | US | claimed |
| WO-2011079036-A1 | BENZAMIDE DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2011-06-30 | — | — | WO | claimed |
| US-9221773-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221773-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221773-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| US-20130045982-A1 | BENZAMIDE DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2013-02-21 | — | — | US | disclosed |
| US-20130045982-A1 | BENZAMIDE DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2013-02-21 | — | — | US | disclosed |
| US-20130045982-A1 | BENZAMIDE DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2013-02-21 | — | — | US | disclosed |
| WO-2011079036-A1 | BENZAMIDE DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130045982-A1 | BENZAMIDE DERIVATIVES | BAD, BAK1, BRDT | HDAC1 39/4885HDAC6 27/4885HDAC8 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.