Sugi Predict

Sugi Predict / Compounds / SCHEMBL942259

SCHEMBL942259

SCHEMBL942259

COc1ccc(C(=O)NO)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 4/20 1.00
▸ CA2 P00918 4/20 1.00
▸ PLK1 P53350 1/20 0.70
▸ HDAC6 Q9UBN7 5/20 0.66
▸ HDAC1 Q13547 4/20 0.66
▸ HDAC8 Q9BY41 3/20 0.66
▸ NPC1 O15118 3/20 0.66
▸ RAB9A P51151 3/20 0.66
▸ TP53 P04637 2/20 0.66
▸ SMN1; SMN2 Q16637 2/20 0.66
▸ ALOX15 P16050 1/20 0.66
▸ CES2 O00748 1/20 0.61
▸ CES1 P23141 1/20 0.61
▸ F10 P00742 1/20 0.61
▸ ALDH1A1 P00352 2/20 0.61
▸ CYP3A4 P08684 2/20 0.61
▸ MAPT P10636 2/20 0.61
▸ MEN1 O00255 1/20 0.59
▸ CYP1A2 P05177 1/20 0.59
▸ GAA P10253 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8880498 0.98 CA1 (0.96) CA1CA2PLK1HDAC6HDAC1
SCHEMBL674669 0.89 NPC1 (0.86) CA1CA2HDAC6HDAC1HDAC8
SCHEMBL28610713 0.88 CA1 (0.77) CA1CA2HDAC6HDAC1HDAC8
SCHEMBL8717056 0.84 PLK1 (0.80) CA1CA2PLK1NPC1RAB9A
SCHEMBL11705060 0.84 MAPT (0.79) CA1CA2PLK1NPC1RAB9A
SCHEMBL15480658 0.83 CA1 (0.70) CA1CA2PLK1HDAC6HDAC1
SCHEMBL12279565 0.83 CA1 (0.70) CA1CA2PLK1HDAC6HDAC1
SCHEMBL29040010 0.83 F3 (0.82) CA1CA2NPC1RAB9AALDH1A1
SCHEMBL10839189 0.83 CA1 (0.70) CA1CA2HDAC6HDAC1HDAC8
SCHEMBL837307 0.83 PLK1 (1.00) CA1CA2PLK1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119176819-B Method for preparing 3, 6-dihydro-1, 2-oxazine derivative by iodine catalysis in aqueous phase 山东第二医科大学 2025-02-14 — — CN claimed
CN-119176819-A Method for preparing 3, 6-dihydro-1, 2-oxazine derivative by iodine catalysis in aqueous phase 山东第二医科大学 2024-12-24 — — CN claimed
US-11981648-B2 Method for the synthesis of 3-R-1,4,2-dioxazol-5-ones TESLA, INC. (US) 2024-05-14 — — US claimed
US-20230029852-A1 METHOD FOR THE SYNTHESIS OF 3-R-1,4,2-DIOXAZOL-5-ONES PANASONIC HOLDINGS CORPORATION (JP) 2023-02-02 — — US claimed
EP-1461010-A2 HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS Integriderm, Inc. (US) 2004-09-29 — — EP claimed
US-20030199558-A1 Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners INTEGRIDERM, INC. 2003-10-23 — — US claimed
WO-2003057184-A2 HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS INTEGRIDERM, INC. (US) 2003-07-17 — — WO claimed
US-20250297134-A1 HIGH RATE BULK OXIDE CMP COMPOSITION ENTEGRIS, INC. 2025-09-25 — — US disclosed
CN-119735513-A Synthesis method of unprotected 1, 2-amino ester and oxazoline derivative 合肥工业大学 2025-04-01 — — CN disclosed
CN-119634050-A Cassiterite collecting agent and preparation method and application thereof 中南大学 2025-03-18 — — CN disclosed
CN-119176819-B Method for preparing 3, 6-dihydro-1, 2-oxazine derivative by iodine catalysis in aqueous phase 山东第二医科大学 2025-02-14 — — CN disclosed
CN-119176819-A Method for preparing 3, 6-dihydro-1, 2-oxazine derivative by iodine catalysis in aqueous phase 山东第二医科大学 2024-12-24 — — CN disclosed
CN-118724753-A Method for promoting synthesis of hydroxamic acid by using metal salt 沈阳药科大学 2024-10-01 — — CN disclosed
WO-2003057184-A2 HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS INTEGRIDERM, INC. (US) 2003-07-17 — — WO disclosed
CN-1040105-C Aminoketone derivatives and use thereof MITZUI TOATSU CHEMICALS INC (JP) 1998-10-07 — — CN disclosed
US-4999366-A Treatment of hyperlipidemia THE NORTH CAROLINA CENTRAL UNIV. (US) 1991-03-12 — — US disclosed
CN-1049660-A Aminoketone derivative and application thereof MITZUI TOATSU CHEMICALS INC (JP) 1991-03-06 — — CN disclosed
US-4946963-A HYPOLIPIDEMIC AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1990-08-07 — — US disclosed
EP-0321090-A2 Isoxazolidine-3,5-diones in the treatment of hyperlipidemia THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 1989-06-21 — — EP disclosed
US-3978208-A ACETOHYDROXAMIC ACID EISAI CO., LTD. (JA) 1976-08-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030199558-A1 Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners TYR, MC1R, MITF CA1 3769/4885CA2 346/4885PLK1 1672/4885
US-11981648-B2 Method for the synthesis of 3-R-1,4,2-dioxazol-5-ones CYP4X1, DDO, CYP4B1 CA1 1290/4885CA2 2900/4885PLK1 2734/4885
US-20230029852-A1 METHOD FOR THE SYNTHESIS OF 3-R-1,4,2-DIOXAZOL-5-ONES CYP4X1, DDO, CYP4B1 CA1 1290/4885CA2 2900/4885PLK1 2734/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.