SCHEMBL20188199

SCHEMBL20188199

CC(C)(O)COc1cc(CCNS(=O)(=O)CCC=CCN2CC(=O)NC2=O)ccc1F

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DUT P33316 16/20 0.50
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20187893 0.87 DUT (0.57) DUTSMN1; SMN2
SCHEMBL20191210 0.86 DUT (0.54) DUT
SCHEMBL18374400 0.84 DUT (0.48) DUT
SCHEMBL20188421 0.83 DUT (0.56) DUT
SCHEMBL18374219 0.83 DUT (0.56) DUT
SCHEMBL20187932 0.82 DUT (0.52) DUT
SCHEMBL20193324 0.80 SMN1; SMN2 (0.40) SMN1; SMN2
SCHEMBL18374408 0.78 DUT (0.46) DUT
SCHEMBL18374223 0.77 DUT (0.55) DUT
SCHEMBL22723272 0.77 DUT (0.55) DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018098206-A1 HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CV6 THERAPEUTICS (NI) LIMITED (GB) 2018-05-31 WO disclosed