Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 17/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019823 | 0.89 | ADORA3 (0.48) | ADORA3HIF1AADORA2AMAPK8 | |
| SCHEMBL12476646 | 0.89 | ADORA3 (0.55) | ADORA3ADORA2AADORA1MAPK8BACE1 | |
| SCHEMBL12575076 | 0.86 | ADORA3 (0.60) | ADORA3HIF1AADORA2AADORA1MAPK8 | |
| SCHEMBL12574975 | 0.85 | ADORA3 (0.59) | ADORA3HIF1AADORA2AADORA1MAPK8 | |
| SCHEMBL12574849 | 0.85 | ADORA3 (0.59) | ADORA3ADORA2AADORA1 | |
| SCHEMBL12637343 | 0.82 | ADORA3 (0.58) | ADORA3HIF1AADORA2AADORA1 | |
| SCHEMBL12638995 | 0.82 | ADORA3 (0.56) | ADORA3HIF1AADORA2AADORA1MAPK8 | |
| SCHEMBL12482130 | 0.82 | ADORA3 (0.61) | ADORA3ADORA2AADORA1MAPK8 | |
| SCHEMBL2023990 | 0.79 | ADORA3 (0.56) | ADORA3ADORA2AMAPK8 | |
| SCHEMBL12574847 | 0.79 | ADORA3 (0.43) | ADORA3HIF1AADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329705-B2 | Substituted triazolo-pyrazine compounds | ARQULE, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329705-B2 | Substituted triazolo-pyrazine compounds | ARQULE, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329705-B2 | Substituted triazolo-pyrazine compounds | ARQULE, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| WO-2011082267-A2 | SUBSTITUTED TRIAZOLO-PYRAZINE COMPOUNDS | ARQULE, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | ADORA3 1835/4885HIF1A 2721/4885ADORA2A 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.