Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.39 |
| ▸ | GSK3A | P49840 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 4/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29742200 | 1.00 | MAPK10 (0.39) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL20209722 | 1.00 | MAPK10 (0.39) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL29742325 | 0.92 | MAPK10 (0.40) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL20189887 | 0.92 | MAPK10 (0.40) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL20209251 | 0.92 | MAPK10 (0.40) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL29742268 | 0.88 | ADRA1D (0.42) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL20189514 | 0.88 | ADRA1D (0.42) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL20190708 | 0.82 | GSK3A (0.42) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL29742368 | 0.82 | MAPK10 (0.41) | MAPK10GSK3AGSK3BMAPK8KDR | |
| SCHEMBL20189471 | 0.82 | MAPK10 (0.41) | MAPK10GSK3AGSK3BMAPK8KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544968-A1 | PYRIMIDINE CARBOXAMIDES AS GSK-3 INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018098413-A1 | PYRIMIDINE CARBOXAMIDES AS GSK-3 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-31 | — | — | WO | disclosed |