Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 15/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20190097 | 1.00 | APLNR (0.48) | APLNRACLYTAS2R14LMNAMEN1 | |
| SCHEMBL20190581 | 1.00 | APLNR (0.48) | APLNRACLYTAS2R14LMNAMEN1 | |
| SCHEMBL18245914 | 0.77 | APLNR (0.61) | APLNRTAS2R14 | |
| SCHEMBL18245917 | 0.77 | APLNR (0.61) | APLNRTAS2R14 | |
| SCHEMBL18246361 | 0.77 | APLNR (0.61) | APLNRTAS2R14 | |
| SCHEMBL20189491 | 0.77 | APLNR (0.58) | APLNRTAS2R14 | |
| SCHEMBL20189985 | 0.77 | APLNR (0.58) | APLNRTAS2R14 | |
| SCHEMBL20189489 | 0.77 | APLNR (0.58) | APLNRTAS2R14 | |
| SCHEMBL22119648 | 0.74 | APLNR (0.59) | APLNRTAS2R14 | |
| SCHEMBL20188403 | 0.72 | APLNR (0.41) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541805-B1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC (US) | 2020-10-14 | — | — | EP | disclosed |
| EP-3541805-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | Amgen Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |