Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.79 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.79 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.79 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.79 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.49 |
| ▸ | ACVR1B | P36896 | 9/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018500 | 1.00 | MAP2K1 (0.79) | MAP2K1MAP2K2PRKCZIARS2TGFBR1 | |
| SCHEMBL2018933 | 1.00 | MAP2K1 (0.79) | MAP2K1MAP2K2PRKCZIARS2TGFBR1 | |
| Pimasertib SCHEMBL22046269 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2 | |
| Pimasertib SCHEMBL29604438 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2 | |
| Pimasertib SCHEMBL2720659 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2 | |
| Pimasertib SCHEMBL2021184 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2 | |
| Pimasertib SCHEMBL29358435 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2 | |
| Pimasertib SCHEMBL18260054 | 0.88 | MAP2K1 (0.98) | MAP2K1MAP2K2PRKCZIARS2 | |
| Pimasertib SCHEMBL29867955 | 0.88 | MAP2K1 (0.98) | MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL2018104 | 0.87 | MAP2K1 (0.72) | MAP2K1MAP2K2PRKCZIARS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841459-B2 | 3-arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2014-09-23 | — | — | US | disclosed |
| US-8841459-B2 | 3-arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2014-09-23 | — | — | US | disclosed |
| US-20140051686-A1 | 3-Arylamino Pyridine Derivatives | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2014-02-20 | — | — | US | disclosed |
| US-20140051686-A1 | 3-Arylamino Pyridine Derivatives | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2014-02-20 | — | — | US | disclosed |
| EP-1802579-B1 | Derivatives of 3-arylaminopyridine | MERCK SERONO SA (CH) | 2013-11-20 | — | — | EP | disclosed |
| US-8524911-B2 | 3-arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2013-09-03 | — | — | US | disclosed |
| US-8524911-B2 | 3-arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2013-09-03 | — | — | US | disclosed |
| US-20120295889-A1 | 3-Arylamino Pyridine Derivatives | MERCK SERONO S.A. (CH) | 2012-11-22 | — | — | US | disclosed |
| US-20120295889-A1 | 3-Arylamino Pyridine Derivatives | MERCK SERONO S.A. (CH) | 2012-11-22 | — | — | US | disclosed |
| US-8198457-B2 | 3-arylamino pyridine derivatives | MERCK SERONO S.A. (CH) | 2012-06-12 | — | — | US | disclosed |
| US-20110224192-A1 | 3-Arylamino Pyridine Derivatives | MERCK SERONO SA (CH) | 2011-09-15 | — | — | US | disclosed |
| US-20110224192-A1 | 3-Arylamino Pyridine Derivatives | MERCK SERONO SA (CH) | 2011-09-15 | — | — | US | disclosed |
| US-7956191-B2 | 3-arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2011-06-07 | — | — | US | disclosed |
| US-7956191-B2 | 3-arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2011-06-07 | — | — | US | disclosed |
| US-7956191-B2 | 3-arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2011-06-07 | — | — | US | disclosed |
| US-20090093462-A1 | 3-Arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2009-04-09 | — | — | US | disclosed |
| US-20090093462-A1 | 3-Arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2009-04-09 | — | — | US | disclosed |
| US-20090093462-A1 | 3-Arylamino pyridine derivatives | MERCK SERONO SA (CH) | 2009-04-09 | — | — | US | disclosed |
| EP-1802579-A1 | 3-ARYLAMINO PYRIDINE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006045514-A1 | 3-ARYLAMINO PYRIDINE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224192-A1 | 3-Arylamino Pyridine Derivatives | MAPK3, BRAF, NRAS | MAP2K1 105/4885MAP2K2 104/4885PRKCZ 1803/4885 |
| US-20120295889-A1 | 3-Arylamino Pyridine Derivatives | MAPK3, BRAF, NRAS | MAP2K1 105/4885MAP2K2 104/4885PRKCZ 1803/4885 |
| US-20140051686-A1 | 3-Arylamino Pyridine Derivatives | MAPK3, BRAF, NRAS | MAP2K1 105/4885MAP2K2 104/4885PRKCZ 1803/4885 |
| US-20090093462-A1 | 3-Arylamino pyridine derivatives | CDK4, BRAF, CDK3 | MAP2K1 119/4885MAP2K2 116/4885PRKCZ 1909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.