Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pimasertib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 known ✓ | Q02750 | 19/20 | 1.00 |
| ▸ | MAP2K2 known ✓ | P36507 | 2/20 | 1.00 |
| ▸ | PRKCZ | Q05513 | 1/20 | 1.00 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 1.00 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimasertib SCHEMBL29358435 | 1.00 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL22046269 | 1.00 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL2021184 | 1.00 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL2720659 | 1.00 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL18260054 | 0.99 | MAP2K1 (0.98) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL29867955 | 0.99 | MAP2K1 (0.98) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| SCHEMBL31108067 | 0.92 | MAP2K1 (0.85) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| SCHEMBL2018933 | 0.88 | MAP2K1 (0.79) | MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL2019046 | 0.88 | MAP2K1 (0.79) | MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL2018500 | 0.88 | MAP2K1 (0.79) | MAP2K1MAP2K2PRKCZIARS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4243819-A1 | KINASE INHIBITOR COMBINATIONS FOR CANCER TREATMENT | Merck Patent GmbH (DE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022101459-A1 | KINASE INHIBITOR COMBINATIONS FOR CANCER TREATMENT | MERCK PATENT GMBH (DE) | 2022-05-19 | — | — | WO | disclosed |