Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 8/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20193161 | 0.92 | CHUK (0.42) | CHUKPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL20193155 | 0.89 | CHUK (0.38) | CHUKFEN1 | |
| SCHEMBL16608618 | 0.88 | CHUK (0.44) | CHUKPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL20193217 | 0.87 | DYRK1A (0.40) | CHUKPIK3CDPIK3CGFEN1 | |
| SCHEMBL19114543 | 0.87 | CHUK (0.35) | CHUK | |
| SCHEMBL20193179 | 0.86 | CREBBP (0.32) | CHUKFEN1 | |
| SCHEMBL20193185 | 0.85 | CHUK (0.63) | CHUK | |
| SCHEMBL20193214 | 0.85 | CHUK (0.41) | CHUKFEN1 | |
| SCHEMBL20193244 | 0.85 | PIK3CD (0.33) | CHUKPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL19114436 | 0.84 | CHUK (0.38) | CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981963-B2 | 3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-29 | — | — | US | disclosed |