Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 6/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | FER | P16591 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20193217 | 0.90 | DYRK1A (0.40) | CHUKFEN1GSK3BNFATC1DYRK1A | |
| SCHEMBL19114543 | 0.90 | CHUK (0.35) | CHUK | |
| SCHEMBL20193179 | 0.89 | CREBBP (0.32) | CHUKFEN1GSK3BAURKBMET | |
| SCHEMBL20193180 | 0.89 | CHUK (0.43) | CHUKFEN1 | |
| SCHEMBL20193214 | 0.89 | CHUK (0.41) | CHUKFEN1GSK3BNFATC1DYRK1A | |
| SCHEMBL20193161 | 0.88 | CHUK (0.42) | CHUKKITFEN1KDRAURKB | |
| SCHEMBL19114436 | 0.87 | CHUK (0.38) | CHUKDYRK1A | |
| SCHEMBL18013729 | 0.87 | DGAT1 (0.40) | CHUKKITFEN1GSK3BNFATC1 | |
| SCHEMBL20193244 | 0.87 | PIK3CD (0.33) | CHUKFEN1 | |
| SCHEMBL19629511 | 0.86 | DYRK1A (0.39) | CHUKKITFEN1GSK3BNFATC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981963-B2 | 3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-29 | — | — | US | disclosed |