Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.85 |
| ▸ | EBP | Q15125 | 5/20 | 0.85 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.85 |
| ▸ | DHCR7 | Q9UBM7 | 2/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.75 |
| ▸ | DRD3 | P35462 | 2/20 | 0.75 |
| ▸ | HTR6 | P50406 | 2/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3'-Methoxy-4'Hydroxyclomiphene SCHEMBL20193223 | 0.92 | ESR1 (1.00) | ESR1EBPESR2DHCR7KMT2A | |
| SCHEMBL14680451 | 0.89 | ESR1 (0.82) | ESR1EBPESR2DHCR7KMT2A | |
| SCHEMBL15788561 | 0.88 | ESR1 (0.67) | ESR1EBPESR2DHCR7KMT2A | |
| Clomiphene SCHEMBL29379763 | 0.87 | ESR1 (1.00) | ESR1EBPESR2DHCR7KMT2A | |
| Enclomiphene SCHEMBL5083138 | 0.87 | ESR1 (1.00) | ESR1EBPESR2DHCR7KMT2A | |
| SCHEMBL10407739 | 0.87 | ESR1 (1.00) | ESR1EBPESR2DHCR7KMT2A | |
| Enclomiphene SCHEMBL34893 | 0.87 | ESR1 (1.00) | ESR1EBPESR2DHCR7KMT2A | |
| Zuclomiphene SCHEMBL34894 | 0.87 | ESR1 (1.00) | ESR1EBPESR2DHCR7KMT2A | |
| Enclomiphene SCHEMBL20594021 | 0.87 | ESR1 (1.00) | ESR1EBPESR2DHCR7KMT2A | |
| Enclomiphene SCHEMBL407458 | 0.85 | ESR1 (0.97) | ESR1EBPESR2DHCR7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351527-A1 | TRANS-CLOMIPHENE METABOLITES AND USES THEREOF | Repros Therapeutics Inc. (US) | 2018-07-25 | — | — | EP | disclosed |
| US-9981906-B2 | Trans-clomiphene metabolites and uses thereof | REPROS THERAPEUTICS INC. (US) | 2018-05-29 | — | — | US | disclosed |