Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 9/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CDC25A | P30304 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22449556 | 0.76 | CDC25A (0.38) | APEX1IDO1LMNACDC25ACDC25B | |
| SCHEMBL8248751 | 0.75 | IDO1 (0.48) | APEX1IDO1LMNACDC25ACDC25B | |
| SCHEMBL8368999 | 0.71 | IDO1 (0.44) | APEX1IDO1LMNACDC25ACDC25B | |
| SCHEMBL22882763 | 0.69 | IDO1 (0.44) | APEX1IDO1LMNACDC25ACDC25B | |
| SCHEMBL13227495 | 0.68 | APEX1 (0.68) | APEX1IDO1LMNACDC25ACDC25B | |
| SCHEMBL13479450 | 0.68 | IDO1 (0.40) | APEX1IDO1LMNAMAPTTDP1 | |
| Aurantiogliocladin SCHEMBL487583 | 0.67 | MAPT (0.50) | APEX1IDO1LMNACDC25ACDC25B | |
| SCHEMBL5455307 | 0.67 | CDC25A (0.48) | APEX1IDO1LMNACDC25ACDC25B | |
| SCHEMBL15944061 | 0.66 | CDC25A (0.52) | APEX1IDO1LMNACDC25ACDC25B | |
| SCHEMBL6577669 | 0.66 | IDO1 (0.37) | APEX1IDO1LMNACDC25ACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9982009-B2 | Methods for treating polycystic kidney disease and polycystic liver disease | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2018-05-29 | — | — | US | disclosed |