Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194140 | 0.78 | F2 (0.46) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL14430274 | 0.78 | F2 (0.63) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20194141 | 0.76 | F2 (0.47) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL24761126 | 0.76 | F2 (0.42) | F2PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL25744914 | 0.73 | PRSS1 (0.68) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL231914 | 0.71 | PRSS1 (0.95) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL11708492 | 0.71 | F2 (0.48) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL11708486 | 0.71 | F2 (0.48) | F2PLGPRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL5899967 | 0.70 | PRSS1 (1.00) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL29841359 | 0.70 | PBRM1 (0.61) | F2PLGPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |