Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194136 | 0.78 | ALDH1A1 (0.44) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL20194158 | 0.74 | GRIN2D (0.35) | F2PLGPRSS1ALDH1A1 | |
| SCHEMBL20194130 | 0.73 | F2 (0.45) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL16016157 | 0.68 | F2 (0.59) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL3650360 | 0.66 | NPSR1 (0.59) | KMT2AGAAADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL5899967 | 0.63 | PRSS1 (1.00) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL14430274 | 0.63 | F2 (0.63) | F2PLGPRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL616601 | 0.63 | PRSS1 (1.00) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL9254112 | 0.63 | PBRM1 (0.55) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL24028062 | 0.62 | MEN1 (0.44) | F2PLGPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |