Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194214 | 0.77 | AAK1 (0.61) | AAK1EGFRKDR | |
| SCHEMBL16635577 | 0.70 | AAK1 (1.00) | AAK1 | |
| SCHEMBL16636115 | 0.70 | AAK1 (1.00) | AAK1EGFRKDR | |
| SCHEMBL20194248 | 0.69 | AAK1 (0.58) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL20194146 | 0.67 | FURIN (0.32) | — | |
| SCHEMBL20194246 | 0.66 | AAK1 (0.56) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL1461105 | 0.66 | KDR (1.00) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL20194221 | 0.65 | AAK1 (0.52) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL13495954 | 0.63 | MAP4K4 (1.00) | AAK1EGFRKDRMAP4K4IRAK4 | |
| SCHEMBL16646845 | 0.63 | AAK1 (1.00) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |