Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194248 | 0.79 | AAK1 (0.58) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL16646774 | 0.72 | AAK1 (0.57) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL16646845 | 0.72 | AAK1 (1.00) | AAK1 | |
| SCHEMBL20194221 | 0.71 | AAK1 (0.52) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL20194209 | 0.66 | AAK1 (0.61) | AAK1EGFR | |
| SCHEMBL20194181 | 0.66 | AAK1 (0.63) | AAK1EGFR | |
| SCHEMBL20194239 | 0.66 | AAK1 (0.54) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL25083972 | 0.63 | MAP4K4 (1.00) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL1461105 | 0.62 | KDR (1.00) | AAK1EGFRKDRMAP4K4 | |
| SCHEMBL16635577 | 0.61 | AAK1 (1.00) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |