Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.52 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194227 | 0.72 | AAK1 (0.51) | AAK1RHOA | |
| SCHEMBL20194163 | 0.71 | AAK1 (0.38) | AAK1EGFRERBB2 | |
| SCHEMBL20194169 | 0.71 | AAK1 (0.51) | AAK1BRD4CREBBPEGFRERBB2 | |
| SCHEMBL20194155 | 0.70 | AAK1 (0.53) | AAK1 | |
| SCHEMBL16635967 | 0.68 | AAK1 (1.00) | AAK1EGFRERBB2 | |
| SCHEMBL20194154 | 0.68 | AAK1 (0.46) | AAK1RHOAEGFRERBB2 | |
| SCHEMBL20194179 | 0.68 | F10 (0.44) | AAK1CCR3EGFRERBB2 | |
| SCHEMBL16635818 | 0.67 | AAK1 (1.00) | AAK1EGFRERBB2 | |
| SCHEMBL20194187 | 0.67 | CCR3 (0.34) | AAK1CCR3EGFRERBB2 | |
| SCHEMBL20194170 | 0.66 | F10 (0.37) | AAK1CCR3EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |