SCHEMBL20195244

SCHEMBL20195244

CCn1c(=O)cc(C2CC2)c2cc(C(=O)N(CI)c3ccncc3)ccc21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 2/20 0.36
TUBB4A P04350 1/20 0.35
TUBB P07437 1/20 0.35
TUBA3C P0DPH7 1/20 0.35
TUBA1B P68363 1/20 0.35
TUBA4A P68366 1/20 0.35
TUBB4B P68371 1/20 0.35
TUBB3 Q13509 1/20 0.35
TUBB2A Q13885 1/20 0.35
TUBB8 Q3ZCM7 1/20 0.35
TUBA3E Q6PEY2 1/20 0.35
TUBA1A Q71U36 1/20 0.35
TUBA1C Q9BQE3 1/20 0.35
TUBB6 Q9BUF5 1/20 0.35
TUBB2B Q9BVA1 1/20 0.35
TUBB1 Q9H4B7 1/20 0.35
RAB9A P51151 1/20 0.33
ALDH1A1 P00352 5/20 0.33
PTGER4 P35408 3/20 0.33
KDM4E B2RXH2 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20183653 0.87 NPY5R (0.39) NPY5RTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL20183628 0.79 KDM4E (0.38) NPY5RRAB9AALDH1A1PTGER4KDM4E
SCHEMBL20354309 0.79 CYP3A4 (0.39) RAB9AALDH1A1KDM4EHPGDTSHR
SCHEMBL20183837 0.79 TRPV1 (0.45) NPY5RTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL20183528 0.77 KDM4E (0.48) ALDH1A1PTGER4KDM4ETSHRSMN1; SMN2
SCHEMBL20183811 0.77 ALDH1A1 (0.42) RAB9AALDH1A1PTGER4KDM4EHPGD
SCHEMBL20183593 0.77 BRD4 (0.43) RAB9AALDH1A1PTGER4KDM4EHPGD
SCHEMBL20183551 0.76 KDM4E (0.38) RAB9AALDH1A1KDM4ETSHRHSD17B10
SCHEMBL20183713 0.76 ALDH1A1 (0.40) ALDH1A1PTGER4KDM4EHPGDTSHR
SCHEMBL20183849 0.76 MLNR (0.40) ALDH1A1KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3327004-B1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND FUJIFILM CORP (JP) 2020-11-04 EP disclosed
EP-3327004-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND Fujifilm Corporation (JP) 2018-05-30 EP disclosed