Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.62 |
| ▸ | JAK2 | O60674 | 4/20 | 0.58 |
| ▸ | MMP1 | P03956 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184345 | 0.93 | JAK3 (0.62) | JAK3JAK2MMP1MMP2MMP9 | |
| SCHEMBL20195280 | 0.92 | JAK3 (0.65) | JAK3JAK2MMP2LMNAMAPT | |
| SCHEMBL16245278 | 0.90 | JAK3 (0.79) | JAK3JAK2JAK1 | |
| SCHEMBL16245280 | 0.90 | JAK3 (0.79) | JAK3JAK2JAK1 | |
| SCHEMBL20184367 | 0.85 | JAK3 (0.65) | JAK3JAK2MMP1MMP2MMP9 | |
| SCHEMBL16245383 | 0.82 | JAK3 (0.82) | JAK3JAK2JAK1 | |
| SCHEMBL16245381 | 0.82 | JAK3 (0.82) | JAK3JAK2JAK1 | |
| SCHEMBL20184370 | 0.79 | MMP1 (0.50) | JAK3JAK2MMP1MMP2MMP9 | |
| SCHEMBL20184572 | 0.78 | JAK3 (0.61) | JAK3JAK2LMNAMAPTJAK1 | |
| SCHEMBL20184485 | 0.78 | JAK3 (0.77) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | disclosed |