⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457083 | 0.83 | — | — | |
| SCHEMBL7751515 | 0.80 | — | — | |
| SCHEMBL2175632 | 0.79 | — | — | |
| SCHEMBL5885006 | 0.79 | — | — | |
| SCHEMBL10446817 | 0.77 | — | — | |
| SCHEMBL31361523 | 0.77 | — | — | |
| SCHEMBL10434860 | 0.77 | — | — | |
| SCHEMBL28710352 | 0.77 | — | — | |
| SCHEMBL28222967 | 0.77 | — | — | |
| SCHEMBL7372321 | 0.76 | POLA1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116462603-A | Synthesis method of o-hydroxy/o-aminobenzamide compound | 常州工程职业技术学院 | 2023-07-21 | — | — | CN | claimed |
| CN-116462603-A | Synthesis method of o-hydroxy/o-aminobenzamide compound | 常州工程职业技术学院 | 2023-07-21 | — | — | CN | disclosed |
| CN-116462603-A | Synthesis method of o-hydroxy/o-aminobenzamide compound | 常州工程职业技术学院 | 2023-07-21 | — | — | CN | disclosed |
| CN-116462603-A | Synthesis method of o-hydroxy/o-aminobenzamide compound | 常州工程职业技术学院 | 2023-07-21 | — | — | CN | disclosed |
| US-8519168-B2 | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds | MERCK SHARP & DOHME CORP. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20110160469-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | MERCK SHARP & DOHME LLC | 2011-06-30 | — | — | US | disclosed |
| US-20100249439-A1 | PROCESS FOR CONTROLLED CRYSTAL SIZE IN 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | MERCK SHARP & DOHME CORP. | 2010-09-30 | — | — | US | disclosed |
| CN-101778836-A | Process for controlled crystal size in 1,2-substituted 3,4-dioxo-1-cyclobutene compounds | SCHERING CORP | 2010-07-14 | — | — | CN | disclosed |
| EP-2181102-A1 | PROCESS FOR CONTROLLED CRYSTAL SIZE IN 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | SCHERING CORPORATION (US) | 2010-05-05 | — | — | EP | disclosed |
| EP-2178826-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | SCHERING CORPORATION (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009005801-A1 | PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009005802-A1 | PROCESS FOR CONTROLLED CRYSTAL SIZE IN 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS | SCHERING CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |