Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.58 |
| ▸ | NPC1 | O15118 | 11/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20200097 | 0.95 | PTGS1 (0.57) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11824079 | 0.88 | RAB9A (0.61) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11824996 | 0.84 | RAB9A (0.60) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3440320 | 0.81 | RAB9A (0.66) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL13325928 | 0.79 | RAB9A (0.68) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11825664 | 0.79 | RAB9A (0.61) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL11824355 | 0.79 | RAB9A (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL12916066 | 0.79 | PTGS1 (0.59) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL13325909 | 0.78 | RAB9A (0.83) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL13325735 | 0.77 | RAB9A (0.75) | RAB9ANPC1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148410-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | DANA-FARBER CANCER INSTITUTE, INC. | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148410-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | GLI1, SHH, HRAS | RAB9A 1517/4885NPC1 350/4885KDM4E 914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.