Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 6/20 | 0.35 |
| ▸ | CASP7 | P55210 | 6/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5992485 | 1.00 | HDAC8 (0.36) | HDAC8HDAC6HDAC1CASP3CASP7 | |
| SCHEMBL7287818 | 0.89 | PDK2 (0.39) | HDAC8HDAC6HDAC1CASP3CASP7 | |
| SCHEMBL12409662 | 0.89 | PDK2 (0.39) | HDAC8HDAC6HDAC1CASP3CASP7 | |
| SCHEMBL5991488 | 0.81 | IRAK4 (0.35) | BRD4BRD2PDK2 | |
| SCHEMBL5991631 | 0.81 | PDK2 (0.33) | BRD4BRD2PDK2 | |
| SCHEMBL16031734 | 0.81 | CASP3 (0.32) | CASP3CASP7BRD4BRD2KCNH2 | |
| SCHEMBL5992357 | 0.80 | PDK2 (0.37) | PDK2 | |
| SCHEMBL5993613 | 0.79 | HDAC8 (0.34) | HDAC8HDAC6HDAC1CASP3CASP7 | |
| SCHEMBL16421826 | 0.79 | BRD4 (0.37) | BRD4BRD2 | |
| SCHEMBL12301044 | 0.78 | PDK2 (0.33) | HDAC8HDAC6HDAC1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541792-B1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |