Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 19/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20190016 | 0.79 | APLNR (0.54) | APLNR | |
| SCHEMBL21339342 | 0.77 | APLNR (0.54) | APLNR | |
| SCHEMBL20201176 | 0.77 | APLNR (0.56) | APLNR | |
| SCHEMBL20201030 | 0.76 | APLNR (0.48) | APLNR | |
| SCHEMBL21339473 | 0.74 | APLNR (0.54) | APLNR | |
| SCHEMBL20190522 | 0.73 | APLNR (0.80) | APLNR | |
| SCHEMBL21339043 | 0.70 | APLNR (0.54) | APLNR | |
| SCHEMBL20189973 | 0.68 | APLNR (0.57) | APLNR | |
| SCHEMBL20190606 | 0.68 | APLNR (0.57) | APLNR | |
| SCHEMBL20200535 | 0.67 | APLNR (0.62) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |