Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 8/20 | 0.75 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20201096 | 1.00 | APLNR (0.75) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL18246176 | 0.86 | APLNR (1.00) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL22812895 | 0.86 | APLNR (1.00) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL18474514 | 0.86 | APLNR (1.00) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL19550838 | 0.86 | APLNR (1.00) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL18246523 | 0.86 | APLNR (1.00) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL18246399 | 0.86 | APLNR (1.00) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL27463869 | 0.80 | APLNR (0.67) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL15274514 | 0.80 | APLNR (0.67) | APLNRCCR1CCR5CCR8HDAC6 | |
| SCHEMBL12457569 | 0.80 | APLNR (0.67) | APLNRCCR1CCR5CCR8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |