Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625465 | 0.79 | PTGS1 (0.36) | APLNRJAK2JAK3 | |
| SCHEMBL24080199 | 0.77 | APLNR (0.55) | APLNR | |
| SCHEMBL18254144 | 0.76 | APLNR (0.34) | APLNRJAK2JAK3 | |
| SCHEMBL18254289 | 0.76 | APLNR (0.34) | APLNRJAK2JAK3 | |
| SCHEMBL18254311 | 0.76 | APLNR (0.34) | APLNRJAK2JAK3 | |
| SCHEMBL18254140 | 0.76 | APLNR (0.34) | APLNRJAK2JAK3 | |
| SCHEMBL219272 | 0.75 | APLNR (0.33) | APLNRJAK2JAK3 | |
| SCHEMBL219915 | 0.75 | APLNR (0.41) | APLNRJAK2JAK3 | |
| SCHEMBL12067749 | 0.75 | APLNR (0.33) | APLNRJAK2JAK3 | |
| SCHEMBL219540 | 0.75 | APLNR (0.33) | APLNRJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |