⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10629554 | 0.78 | — | — | |
| SCHEMBL8099062 | 0.78 | — | — | |
| SCHEMBL11418165 | 0.78 | — | — | |
| SCHEMBL661910 | 0.75 | — | — | |
| SCHEMBL11215176 | 0.75 | — | — | |
| SCHEMBL5944339 | 0.73 | — | — | |
| SCHEMBL11415554 | 0.67 | — | — | |
| SCHEMBL563385 | 0.67 | TRPM8 (0.32) | — | |
| SCHEMBL6873597 | 0.67 | TRPM8 (0.32) | — | |
| SCHEMBL575396 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015053980-A1 | PREPARATION OF ORGANOPHOSPHATE PEPTIDE ADDUCTS | BATTELLE MEMORIAL INSTITUTE (US) | 2015-04-16 | — | — | WO | disclosed |
| US-20150099864-A1 | PREPARATION OF ORGANOPHOSPHATE PEPTIDE ADDUCTS | BATTELLE MEMORIAL INSTITUTE | 2015-04-09 | — | — | US | disclosed |
| US-20140243290-A1 | Aminopyrimidines as SYK Inhibitors | ALTMAN MICHAEL D (US) | 2014-08-28 | — | — | US | disclosed |
| US-8759366-B2 | Aminopyrimidines as SYK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-06-24 | — | — | US | disclosed |
| CN-102295778-B | Hyperbranched polyphosphoramidate and preparation method thereof | UNIV XI AN JIAOTONG | 2013-11-06 | — | — | CN | disclosed |
| US-8551984-B2 | Aminopyrimidines as SYK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120277192-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME LLC | 2012-11-01 | — | — | US | disclosed |
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| CN-102295778-A | Hyperbranched polyphosphoramidate and preparation method thereof | — | 2011-12-28 | — | — | CN | disclosed |
| US-20110245205-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME LLC | 2011-10-06 | — | — | US | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |
| EP-0731124-A1 | FLAME RETARDANT POLYESTER | KANEBO, LTD. (JP) | 1996-09-11 | — | — | EP | disclosed |
| US-4605647-A | ANTITUMOR AGENTS; ANTICARCINOGENIC AGENTS | ADIR, S.A.R.L. (FR) | 1986-08-12 | — | — | US | disclosed |
| US-4379877-A | MIXTURE WITH A PHOSPHORUS-CONTAINING COPOLYMER AND MALEIC ANHYDRIDE-STYRENE COPOLYMERJ | ATLANTIC RICHFIELD COMPANY (US) | 1983-04-12 | — | — | US | disclosed |
| US-4376064-A | OXYGENATED COMPOUND OF PHOSPHORUS | STANDARD OIL CO. (INDIANA) (US) | 1983-03-08 | — | — | US | disclosed |
| US-4371672-A | Thermoplastic molding composition | ATLANTIC RICHFIELD COMPANY (US) | 1983-02-01 | — | — | US | disclosed |
| US-4369260-A | Phosphorus-containing alternating copolymers | ATLANTIC RICHFIELD COMPANY (US) | 1983-01-18 | — | — | US | disclosed |
| US-4319913-A | Substituted benzazaphospholes, herbicidal compositions and the use thereof | MONSANTO COMPANY (US) | 1982-03-16 | — | — | US | disclosed |
| US-4156663-A | 260/857 R | KANEBO, LTD. (JP) | 1979-05-29 | — | — | US | disclosed |
| US-4072658-A | FLAME RETARDANTS | KANEBO, LTD. (JA) | 1978-02-07 | — | — | US | disclosed |