Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20201654 | 1.00 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL13419311 | 0.89 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL21324932 | 0.83 | CHRNB4 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL21324922 | 0.83 | CHRNB4 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL20208311 | 0.83 | CHRNB4 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL20376493 | 0.83 | CHRNB4 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL12122986 | 0.81 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA5 | |
| SCHEMBL2202872 | 0.80 | CHRNB4 (0.68) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL2202866 | 0.80 | CHRNB4 (0.68) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2 | |
| SCHEMBL24153920 | 0.78 | SCN9A (0.43) | SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098206-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098207-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |