SCHEMBL20202734

SCHEMBL20202734

C[C@H]1C[C@@H]1c1ccc(F)c(F)c1

nearest known ligand 0.55

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.55
HTR2C P28335 2/20 0.55
HTR2B P41595 2/20 0.55
KDM1A O60341 9/20 0.46
MAOB P27338 1/20 0.46
KCNH2 Q12809 2/20 0.44
KDM1B Q8NB78 1/20 0.44
GRIA4 P48058 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL808747 1.00 HTR2A (0.55) HTR2AHTR2CHTR2BKDM1AMAOB
SCHEMBL20997590 1.00 HTR2A (0.55) HTR2AHTR2CHTR2BKDM1AMAOB
SCHEMBL808663 1.00 HTR2A (0.55) HTR2AHTR2CHTR2BKDM1AMAOB
SCHEMBL13192766 1.00 HTR2A (0.55) HTR2AHTR2CHTR2BKDM1AMAOB
SCHEMBL8329699 0.82 KDM1A (0.41) HTR2AHTR2CHTR2BKDM1AMAOB
SCHEMBL14141377 0.80 GRIA4 (0.51) HTR2AHTR2CHTR2BKDM1AMAOB
SCHEMBL31412689 0.79 KDM1A (0.44) HTR2AHTR2CHTR2BKDM1AMAOB
SCHEMBL23995537 0.79 KDM1A (0.70) HTR2AHTR2CHTR2BKDM1AKCNH2
SCHEMBL23993641 0.79 KDM1A (0.51) HTR2AHTR2CHTR2BKDM1A
SCHEMBL19444133 0.79 KDM1A (0.70) HTR2AHTR2CHTR2BKDM1AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180148745-A1 HEMOPROTEIN CATALYSTS FOR IMPROVED ENANTIOSELECTIVE ENZYMATIC SYNTHESIS OF TICAGRELOR CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2018-05-31 US disclosed