Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 12/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21363618 | 0.74 | TRPA1 (0.47) | TRPA1 | |
| SCHEMBL20187600 | 0.71 | TRPA1 (0.52) | TRPA1SMN1; SMN2 | |
| SCHEMBL20187460 | 0.67 | SMN1; SMN2 (0.45) | TRPA1SMN1; SMN2 | |
| SCHEMBL22210019 | 0.66 | TRPA1 (0.72) | TRPA1 | |
| Hydrochloric Acid SCHEMBL22194465 | 0.65 | TRPA1 (0.71) | TRPA1 | |
| Hydrochloric Acid SCHEMBL22194462 | 0.65 | TRPA1 (0.71) | TRPA1 | |
| Hydrochloric Acid SCHEMBL22194464 | 0.65 | TRPA1 (0.71) | TRPA1 | |
| SCHEMBL22210437 | 0.64 | TRPA1 (0.77) | TRPA1 | |
| SCHEMBL21363471 | 0.63 | TRPA1 (0.37) | TRPA1ALDH1A1LMNA | |
| SCHEMBL22477750 | 0.63 | GSK3A (0.39) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018096159-A1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-31 | — | — | WO | disclosed |