Sugi Predict

Sugi Predict / Compounds / SCHEMBL20203576

SCHEMBL20203576

SCHEMBL20203576

CSc1ncc2cc(C[C@@H](C)OC(=O)c3ccccc3)nc(Cl)c2n1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.39
▸ CYP1A2 P05177 1/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ SCN1A P35498 1/20 0.37
▸ SCN2A Q99250 1/20 0.37
▸ SCN3A Q9NY46 1/20 0.37
▸ POLB P06746 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ MAPT P10636 3/20 0.36
▸ HPGD P15428 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ PKM P14618 1/20 0.35
▸ TP53 P04637 2/20 0.35
▸ NPC1 O15118 2/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20203573 0.83 SMN1; SMN2 (0.37) LMNAPOLBALDH1A1TDP1MAPT
SCHEMBL20207266 0.83 SMN1; SMN2 (0.37) LMNAPOLBALDH1A1TDP1MAPT
SCHEMBL31164152 0.83 KMT2A (0.42) LMNAPOLBALDH1A1TDP1MAPT
SCHEMBL18291265 0.83 KMT2A (0.42) LMNAPOLBALDH1A1TDP1MAPT
SCHEMBL20203574 0.81 PKM (0.44) LMNAPOLBALDH1A1TDP1MAPT
SCHEMBL25271973 0.79 SMN1; SMN2 (0.40) LMNAPOLBALDH1A1TDP1MAPT
SCHEMBL20037735 0.73 TP53 (0.37) LMNAPOLBALDH1A1TDP1MAPT
SCHEMBL20037602 0.73 HASPIN (0.37) LMNACYP1A2CYP2D6SCN1ASCN2A
SCHEMBL20037634 0.72 TDP1 (0.43) LMNAPOLBALDH1A1TDP1MAPT
SCHEMBL20203400 0.72 TP53 (0.44) LMNAPOLBMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11084814-B2 Pyrido[3, 4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof TEIJIN PHARMA LIMITED (JP) 2021-08-10 — — US disclosed
WO-2018097297-A1 PYRIDO[3, 4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF 帝人ファーマ株式会社 2018-05-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11084814-B2 Pyrido[3, 4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof CDK4, CDK6, CDK16 LMNA 3711/4885CYP1A2 2489/4885CYP2D6 95/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.