Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23733423 | 0.94 | TP53 (0.45) | TP53TDP1ALDH1A1POLBNTRK1 | |
| SCHEMBL20203627 | 0.90 | RXFP1 (0.43) | TP53TDP1ALDH1A1POLBNTRK1 | |
| SCHEMBL20203536 | 0.89 | POLB (0.38) | TP53TDP1ALDH1A1POLBNTRK1 | |
| SCHEMBL20203533 | 0.86 | TP53 (0.36) | TP53TDP1ALDH1A1POLBNTRK1 | |
| SCHEMBL20203618 | 0.84 | TDP1 (0.39) | TP53TDP1ALDH1A1POLBNTRK1 | |
| SCHEMBL20037634 | 0.83 | TDP1 (0.43) | TP53TDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL31164152 | 0.83 | KMT2A (0.42) | TP53TDP1ALDH1A1POLBMAPT | |
| SCHEMBL18291265 | 0.83 | KMT2A (0.42) | TP53TDP1ALDH1A1POLBMAPT | |
| SCHEMBL20203620 | 0.81 | JAK2 (0.40) | TP53TDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL20203621 | 0.81 | TDP1 (0.37) | TP53TDP1ALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097297-A1 | PYRIDO[3, 4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 帝人ファーマ株式会社 | 2018-05-31 | — | — | WO | disclosed |