Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 8/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26539405 | 0.92 | CYP1A2 (0.46) | CYP1A2SCN5AFYNCHEK1CHEK2 | |
| SCHEMBL20203831 | 0.86 | CYP1A2 (0.52) | CYP1A2SCN5AFYNCHEK1CHEK2 | |
| SCHEMBL23571348 | 0.86 | CYP1A2 (0.52) | CYP1A2SCN5AFYNCHEK1CHEK2 | |
| SCHEMBL20190997 | 0.84 | FYN (0.49) | CYP1A2SCN5AFYNCHEK1CHEK2 | |
| SCHEMBL20190957 | 0.82 | MKNK1 (0.50) | CYP1A2SCN5AFYNMAPK14MKNK1 | |
| SCHEMBL20203911 | 0.81 | CYP1A2 (0.64) | CYP1A2SCN5AFYN | |
| SCHEMBL20203724 | 0.80 | CYP1A2 (0.48) | CYP1A2SCN5AFYNMAPK14MKNK2 | |
| SCHEMBL20203731 | 0.80 | CYP1A2 (0.49) | CYP1A2SCN5AFYNMAPK14MKNK1 | |
| SCHEMBL26539431 | 0.80 | CYP1A2 (0.54) | CYP1A2SCN5AFYNCHEK1CHEK2 | |
| SCHEMBL20204036 | 0.79 | CYP1A2 (0.54) | CYP1A2SCN5AFYNMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322790-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-10-12 | — | — | US | disclosed |
| US-20230322790-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-10-12 | — | — | US | disclosed |
| US-20210188852-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2021-06-24 | — | — | US | disclosed |
| WO-2018098499-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188852-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | CYP1A2 1988/4885SCN5A 8/4885FYN 1495/4885 |
| US-20230322790-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | CYP1A2 1988/4885SCN5A 8/4885FYN 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.