Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.86 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.84 |
| ▸ | STK3 | Q13188 | 7/20 | 0.84 |
| ▸ | STK4 | Q13043 | 5/20 | 0.84 |
| ▸ | BTK | Q06187 | 2/20 | 0.84 |
| ▸ | SRC | P12931 | 2/20 | 0.84 |
| ▸ | KDR | P35968 | 2/20 | 0.84 |
| ▸ | STK25 | O00506 | 1/20 | 0.84 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.84 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.84 |
| ▸ | GAK | O14976 | 1/20 | 0.84 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.84 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.84 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.84 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.84 |
| ▸ | STK17B | O94768 | 1/20 | 0.84 |
| ▸ | STK10 | O94804 | 1/20 | 0.84 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.84 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.84 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17570820 | 0.94 | EGFR (0.88) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL18780473 | 0.93 | EGFR (0.87) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL31661612 | 0.93 | EGFR (0.87) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL28970453 | 0.93 | EGFR (0.85) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL30185817 | 0.93 | EGFR (0.85) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL15320949 | 0.92 | EGFR (1.00) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL4962501 | 0.92 | EGFR (0.84) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL4962504 | 0.92 | EGFR (0.84) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL20204906 | 0.92 | EGFR (0.88) | EGFRERBB2STK3STK4BTK | |
| SCHEMBL22847992 | 0.92 | EGFR (0.85) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11789025-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-10969394-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-20210072254-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | DANA-FARBER CANCER INSTITUTE, INC. | 2021-03-11 | — | — | US | disclosed |
| US-20190346454-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | DANA-FARBER CANCER INSTITUTE, INC. | 2019-11-14 | — | — | US | disclosed |
| WO-2018098473-A1 | REAGENTS AND METHODS FOR ANALYSIS OF PROTEINS AND METABOLITES TARGETED BY COVALENT PROBES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10969394-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | PTMS, SRMS, HSP90B1 | EGFR 3656/4885ERBB2 3194/4885STK3 3024/4885 |
| US-11789025-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | PTMS, SRMS, HSP90B1 | EGFR 3656/4885ERBB2 3194/4885STK3 3024/4885 |
| US-20210072254-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | PTMS, SRMS, HSP90B1 | EGFR 3656/4885ERBB2 3194/4885STK3 3024/4885 |
| US-20190346454-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | PTMS, SRMS, HSP90B1 | EGFR 3656/4885ERBB2 3194/4885STK3 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.