Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148024 | 0.85 | RET (0.43) | RETSMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL20158638 | 0.83 | RET (0.41) | RETSMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL20148011 | 0.82 | RET (0.42) | RETSMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL22856992 | 0.77 | RORC (0.34) | RETKMT2AMEN1EPHX2 | |
| SCHEMBL14606172 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1LMNANPSR1ALDH1A1 | |
| SCHEMBL30513444 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1LMNANPSR1ALDH1A1 | |
| SCHEMBL20069206 | 0.71 | HRH3 (0.37) | RETSMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL32691055 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1LMNANPSR1ALDH1A1 | |
| SCHEMBL8908114 | 0.71 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1LMNANPSR1ALDH1A1 | |
| SCHEMBL30419080 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1LMNANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | RET 1/4885SMN1; SMN2 646/4885NPC1 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.