Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.59 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20206127 | 0.96 | NAMPT (0.57) | NAMPTGRM5GAAKDM4EMEN1 | |
| SCHEMBL20206151 | 0.95 | GAA (0.51) | NAMPTGRM5GAAKDM4EMEN1 | |
| SCHEMBL20206125 | 0.91 | NAMPT (0.52) | NAMPTGRM5GAAKDM4EMEN1 | |
| SCHEMBL20189983 | 0.88 | STAT3 (0.52) | NAMPTGRM5GAAKDM4EMEN1 | |
| SCHEMBL24021427 | 0.88 | GRM5 (0.49) | NAMPTGRM5GAAKDM4EMEN1 | |
| SCHEMBL20206126 | 0.87 | KAT6A (0.52) | NAMPTGRM5MEN1KMT2ACYP17A1 | |
| SCHEMBL23898933 | 0.86 | GAA (0.61) | NAMPTGAAKDM4EMEN1KMT2A | |
| SCHEMBL20206136 | 0.85 | NAMPT (0.45) | NAMPTGRM5GAAKDM4EMEN1 | |
| SCHEMBL24021470 | 0.83 | NAMPT (0.41) | NAMPTGRM5GAAKDM4EMEN1 | |
| SCHEMBL24021477 | 0.82 | GRM5 (0.46) | NAMPTGRM5KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544970-B1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA FARBER CANCER INST INC (US) | 2021-11-17 | — | — | EP | disclosed |
| WO-2018098367-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |