Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24021477 | 0.92 | GRM5 (0.46) | NAMPTACKR3KDM4EMEN1KMT2A | |
| SCHEMBL20206254 | 0.92 | GRM5 (0.46) | NAMPTACKR3KDM4EMEN1KMT2A | |
| SCHEMBL20206222 | 0.89 | ACKR3 (0.47) | NAMPTACKR3KDM4EMEN1KMT2A | |
| SCHEMBL20206152 | 0.85 | NAMPT (0.59) | NAMPTKDM4EMEN1KMT2AGRM5 | |
| SCHEMBL21328550 | 0.84 | MEN1 (0.47) | KDM4EMEN1KMT2ARXFP1GRM5 | |
| SCHEMBL21328551 | 0.84 | MEN1 (0.47) | KDM4EMEN1KMT2ARXFP1GRM5 | |
| SCHEMBL20206134 | 0.83 | KMT2A (0.58) | NAMPTKDM4EMEN1KMT2ARXFP1 | |
| SCHEMBL20206287 | 0.83 | BTK (0.47) | NAMPTACKR3KDM4EMEN1KMT2A | |
| SCHEMBL20206285 | 0.83 | BTK (0.47) | NAMPTACKR3KDM4EMEN1KMT2A | |
| SCHEMBL30165290 | 0.83 | BTK (0.47) | NAMPTACKR3KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544970-B1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA FARBER CANCER INST INC (US) | 2021-11-17 | — | — | EP | disclosed |
| WO-2018098367-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |