Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20189257 | 0.88 | POLB (0.55) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL20189793 | 0.88 | POLB (0.62) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL24021474 | 0.87 | MAPT (0.56) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL20206102 | 0.85 | GRM5 (0.55) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL20766926 | 0.83 | MAPT (0.65) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL20189462 | 0.83 | POLB (0.56) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL24021453 | 0.82 | GRM5 (0.48) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL12468912 | 0.81 | POLB (0.57) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL20189986 | 0.81 | IRAK1 (0.62) | POLBMEN1KMT2AGRM5ALDH1A1 | |
| SCHEMBL20206158 | 0.81 | POLB (0.53) | POLBMEN1KMT2AGRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544970-B1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA FARBER CANCER INST INC (US) | 2021-11-17 | — | — | EP | disclosed |
| WO-2018098367-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |