Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20206125 | 0.85 | NAMPT (0.52) | GAANPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL20206126 | 0.82 | KAT6A (0.52) | ALDH1A1NPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL20206127 | 0.81 | NAMPT (0.57) | GAAALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL24021427 | 0.81 | GRM5 (0.49) | GAAHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20206151 | 0.81 | GAA (0.51) | GAAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20206152 | 0.79 | NAMPT (0.59) | GAAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23898933 | 0.73 | GAA (0.61) | GAAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20189983 | 0.73 | STAT3 (0.52) | GAAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7074306 | 0.70 | NAMPT (0.57) | ALDH1A1NPC1RAB9AHDAC3HDAC1 | |
| SCHEMBL20206124 | 0.70 | P2RY14 (0.49) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098367-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |