Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26258651 | 0.81 | ANPEP (0.32) | — | |
| SCHEMBL4653047 | 0.81 | TSHR (0.36) | TSHR | |
| SCHEMBL11526148 | 0.81 | TSHR (0.36) | TSHR | |
| SCHEMBL23299704 | 0.78 | — | — | |
| SCHEMBL598883 | 0.76 | ALDH1A1 (0.35) | CYP3A4TSHRTDP1 | |
| SCHEMBL20118705 | 0.75 | CYP3A4 (0.32) | CYP3A4CYP2D6TSHRNFKB1THPO | |
| SCHEMBL26000373 | 0.75 | ANPEP (0.30) | — | |
| SCHEMBL28167341 | 0.74 | TSHR (0.32) | TSHR | |
| SCHEMBL11726366 | 0.72 | CACNA2D1 (0.46) | TSHRTDP1 | |
| SCHEMBL22779212 | 0.72 | CACNA2D1 (0.46) | CYP3A4CYP2D6TSHRNFKB1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098352-A2 | TARGETING KRAS INDUCED IMMUNE CHECKPOINT EXPRESSION | OISHI JUN (JP) | 2018-05-31 | — | — | WO | disclosed |