Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 9/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18523078 | 1.00 | APLNR (0.32) | APLNRNPC1LMNAMAPTRAB9A | |
| SCHEMBL23612822 | 1.00 | APLNR (0.32) | APLNRNPC1LMNAMAPTRAB9A | |
| SCHEMBL30168086 | 0.80 | NPC1 (0.36) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL179362 | 0.80 | NPC1 (0.36) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL13094057 | 0.77 | KDM4E (0.30) | NPC1RAB9A | |
| SCHEMBL16504272 | 0.77 | KDM4E (0.30) | NPC1RAB9A | |
| SCHEMBL443397 | 0.77 | KDM4E (0.30) | NPC1RAB9A | |
| SCHEMBL18530889 | 0.77 | APLNR (0.32) | APLNRNPC1LMNAMAPTRAB9A | |
| SCHEMBL18254654 | 0.77 | APLNR (0.32) | APLNRNPC1LMNAMAPTRAB9A | |
| SCHEMBL20204744 | 0.76 | APLNR (0.35) | APLNRNPC1LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |