Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18154010 | 0.85 | TRPV1 (0.44) | TRPV1EPHX2MAPTHDAC3HDAC1 | |
| SCHEMBL18154009 | 0.85 | TRPV1 (0.44) | TRPV1EPHX2MAPTHDAC3HDAC1 | |
| SCHEMBL12836091 | 0.81 | NR4A1 (0.63) | TRPV1NR4A1NR4A2NR4A3GAA | |
| SCHEMBL18146421 | 0.81 | NR4A1 (0.63) | TRPV1NR4A1NR4A2NR4A3GAA | |
| SCHEMBL13864073 | 0.79 | TRPV1 (0.47) | TRPV1NR4A1NR4A2NR4A3GAA | |
| SCHEMBL508137 | 0.78 | NR4A1 (0.58) | TRPV1NR4A1NR4A2NR4A3EPHX2 | |
| SCHEMBL15587040 | 0.76 | HDAC3 (0.44) | TRPV1EPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL18146304 | 0.76 | MAOB (0.46) | EPHX2HDAC3HDAC1HDAC2GRIN2B | |
| SCHEMBL18146306 | 0.76 | MAOB (0.46) | EPHX2HDAC3HDAC1HDAC2GRIN2B | |
| SCHEMBL2092955 | 0.76 | TRPV1 (0.45) | TRPV1EPHX2MAPTHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098500-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2018-05-31 | — | — | WO | disclosed |