⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30678356 | 0.79 | — | — | |
| SCHEMBL15962191 | 0.79 | — | — | |
| SCHEMBL15006461 | 0.75 | — | — | |
| SCHEMBL21603318 | 0.75 | — | — | |
| SCHEMBL354180 | 0.72 | — | — | |
| SCHEMBL31150474 | 0.72 | — | — | |
| SCHEMBL23791811 | 0.72 | POLB (0.37) | — | |
| SCHEMBL21608319 | 0.72 | MAPK14 (0.32) | — | |
| SCHEMBL19590673 | 0.72 | POLB (0.32) | — | |
| SCHEMBL21608538 | 0.69 | LMNA (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210277003-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-09 | — | — | US | disclosed |
| CN-107406423-B | Potent gamma-secretase modulators | 通用医疗公司 | 2020-06-16 | — | — | CN | disclosed |
| WO-2019243535-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
| US-20180148464-A1 | TETRADENTATE AND OCTAHEDRAL METAL COMPLEXES CONTAINING NAPHTHYRIDINOCARBAZOLE AND ITS ANALOGUES | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | 2018-05-31 | — | — | US | disclosed |