Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 11/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.51 |
| ▸ | CDK9 | P50750 | 10/20 | 0.51 |
| ▸ | CCNH | P51946 | 9/20 | 0.51 |
| ▸ | CCNK | O75909 | 5/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.51 |
| ▸ | CDK13 | Q14004 | 4/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.50 |
| ▸ | CDK2 | P24941 | 5/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20190962 | 0.93 | CDK7 (0.53) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL20209310 | 0.93 | CDK7 (0.53) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL20209673 | 0.93 | CDK7 (0.49) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL29746692 | 0.90 | CDK7 (0.48) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL22654520 | 0.90 | CDK7 (0.48) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL20191043 | 0.90 | CDK7 (0.48) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL19605654 | 0.85 | CDK7 (0.53) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL16665131 | 0.85 | CDK7 (0.55) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL28346026 | 0.85 | CDK7 (0.49) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL28346025 | 0.85 | CDK7 (0.49) | CDK7CCNT1CDK9CCNHCCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098361-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 12 (CDK12) AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |