Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 10/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 10/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 3/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15930153 | 0.88 | MAPK1 (0.42) | KDM5AKDM4CKDM5BMAPK1HTT | |
| SCHEMBL15933288 | 0.81 | MAPK1 (0.58) | KDM5AKDM4CKDM5BMAPK1HTT | |
| SCHEMBL14692504 | 0.81 | KDM5A (0.50) | KDM5AKDM4CKDM5BMAPK1KDM4A | |
| SCHEMBL14692303 | 0.75 | KDM5A (0.40) | KDM5AKDM4CKDM5BMAPK1HTT | |
| SCHEMBL15180439 | 0.71 | KDM5A (0.52) | KDM5AKDM4CKDM5BMAPK1KDM4A | |
| SCHEMBL20209830 | 0.70 | HTT (0.56) | MAPK1HTTKMT2ARAB9ANPC1 | |
| SCHEMBL14692511 | 0.70 | KDM4C (0.40) | KDM5AKDM4CKDM5BMAPK1KDM4A | |
| SCHEMBL15930155 | 0.68 | LMNA (0.45) | KDM5AKDM4CKDM5BKDM4AKDM2B | |
| SCHEMBL14706023 | 0.68 | KMT2A (0.57) | MAPK1HTTKMT2ARAB9ANPC1 | |
| SCHEMBL15930149 | 0.66 | MAPK1 (0.42) | MAPK1HTTKMT2AKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208068-B2 | Macrocycles as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-19 | — | — | US | disclosed |
| US-20180148461-A1 | NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148461-A1 | NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS | TFPI, TFPI2, F12 | KDM5A 1321/4885KDM4C 1746/4885KDM5B 1380/4885 |
| US-10208068-B2 | Macrocycles as factor XIa inhibitors | TFPI, TFPI2, F12 | KDM5A 1269/4885KDM4C 1789/4885KDM5B 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.