Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.59 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.57 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | CHKA | P35790 | 1/20 | 0.55 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | CD74 | P04233 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1373046 | 0.97 | CYP2D6 (0.67) | CYP2D6CYP2C9HIF1AMEN1ALDH1A1 | |
| SCHEMBL12563565 | 0.96 | CYP2D6 (0.69) | CYP2D6CYP2C9HIF1AMEN1ALDH1A1 | |
| SCHEMBL10145077 | 0.89 | ALDH1A1 (0.60) | CYP2D6CYP2C9HIF1AMEN1ALDH1A1 | |
| SCHEMBL31721209 | 0.89 | ALDH1A1 (0.60) | CYP2D6CYP2C9HIF1AMEN1ALDH1A1 | |
| SCHEMBL2002699 | 0.89 | MEN1 (0.57) | CYP2D6CYP2C9HIF1AMEN1ALDH1A1 | |
| SCHEMBL1512308 | 0.87 | CHRM3 (0.72) | MEN1ALDH1A1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL1013481 | 0.87 | ALDH1A1 (0.62) | MEN1ALDH1A1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL30512200 | 0.87 | ALDH1A1 (0.62) | MEN1ALDH1A1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL13150524 | 0.87 | MEN1 (0.56) | CYP2D6CYP2C9HIF1AMEN1ALDH1A1 | |
| SCHEMBL6630922 | 0.86 | MEN1 (0.61) | CYP2D6CYP2C9HIF1AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210380593-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2021-12-09 | — | — | US | disclosed |
| US-11117898-B2 | Pyrazolo-heteroaryl derivative, preparation method and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-09-14 | — | — | US | disclosed |
| US-20210115046-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-04-22 | — | — | US | disclosed |
| EP-3546457-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2019-10-02 | — | — | EP | disclosed |
| CN-108884092-A | Pyrazolo-heteroaryl analog derivative, preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2018-11-23 | — | — | CN | disclosed |
| WO-2018095426-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115046-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | TLR7, TLR3, TLR4 | CYP2D6 128/4885CYP2C9 137/4885HIF1A 3243/4885 |
| US-11117898-B2 | Pyrazolo-heteroaryl derivative, preparation method and medical use thereof | TLR7, TLR3, TLR4 | CYP2D6 128/4885CYP2C9 137/4885HIF1A 3243/4885 |
| US-20210380593-A1 | PYRAZOLO-HETEROARYL DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF | TLR7, TLR3, TLR4 | CYP2D6 128/4885CYP2C9 137/4885HIF1A 3243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.