Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mitoxantrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | RECQL | P46063 | 3/20 | 1.00 |
| ▸ | NSD2 | O96028 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 1.00 |
| ▸ | CSNK2B | P67870 | 3/20 | 1.00 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 1.00 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | MTOR | P42345 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11391594 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11038495 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Mitoxantrone SCHEMBL29353270 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11036806 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11041207 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Mitoxantrone SCHEMBL29720597 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Mitoxantrone SCHEMBL3000 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11517949 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Mitoxantrone SCHEMBL532914 | 0.98 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Mitoxantrone SCHEMBL3928 | 0.98 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675838-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | Puretecch LYT, Inc. (US) | 2020-07-08 | — | — | EP | disclosed |
| EP-3548005-A1 | EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS | Puretech Health LLC (US) | 2019-10-09 | — | — | EP | disclosed |
| WO-2019046491-A1 | LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS | ARIYA THERAPEUTICS, INC. (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2018102397-A1 | EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS | PureTech Health LLC (US) | 2018-06-07 | — | — | WO | disclosed |
| CN-106714822-A | Combination therapy for treatment of cancer | 昂科梅德制药有限公司 | 2017-05-24 | — | — | CN | disclosed |