Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mitoxantrone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | RECQL | P46063 | 3/20 | 1.00 |
| ▸ | NSD2 | O96028 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 1.00 |
| ▸ | CSNK2B | P67870 | 3/20 | 1.00 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 1.00 |
| ▸ | CSNK2A3 | Q8NEV1 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | MTOR | P42345 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mitoxantrone SCHEMBL20214110 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Mitoxantrone SCHEMBL29353270 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11038495 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11036806 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11517949 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11391594 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Mitoxantrone SCHEMBL29720597 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| SCHEMBL11041207 | 1.00 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Mitoxantrone SCHEMBL2342900 | 0.98 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA | |
| Hydrochloric Acid SCHEMBL10522176 | 0.98 | MEN1 (1.00) | MEN1KMT2AMAPK1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 181702 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4749286-A2 | METHOD OF ASSESSING RISK OF PML | Biogen MA Inc. (US) | 2026-05-27 | — | — | EP | claimed |
| EP-4748859-A2 | CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF | The Regents of the University of California (US) | 2026-05-27 | — | — | EP | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| EP-4747263-A1 | LIPID NANOPARTICLES AND USES THEREOF | University of Connecticut (US) | 2026-05-27 | — | — | EP | claimed |
| CN-224285143-U | Dihydroxyanthraquinone is with high-efficient dewatering device | Inner Mongolia Baohong Chemical Technology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-116209439-B | Cereblon protein modulators | Saint Jude Children's Research Hospital Ltd. (US) | 2026-05-26 | — | — | CN | claimed |
| US-20260137671-A1 | PDK4 as a Cell-Aging Intervention Target and Its Use in Chemotherapy and Anticancer | SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES (CN) | 2026-05-21 | — | — | US | claimed |
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| WO-2026102563-A1 | DISUBSTITUTED PYRIMIDOPYRROLE ANALOG AND USE THEREOF | 深圳湾实验室坪山生物医药研发转化中心 | 2026-05-21 | — | — | WO | claimed |
| WO-2026105121-A1 | ANTICANCER FORMULATIONS AND USES THEREOF | INTRAGEL THERAPEUTICS LTD. (IL) | 2026-05-21 | — | — | WO | claimed |
| US-4292248-A | BY HEATING THE CORRESPONDING DINITRO COMPOUND WITH SODIUM OR POTASSIUM FORMATE IN DIMETHYLFORMAMIDE | AMERICAN COLOR & CHEMICAL CORPORATION (US) | 1981-09-29 | — | — | US | claimed |
| EP-0000341-B1 | PROCESS FOR PREPARING PRACTICALLY PURE 1-AMINO-8-NITRO-4,5-DIHYDROXY ANTHRAQUINONE | BASF Aktiengesellschaft (DE) | 1981-02-25 | — | — | EP | claimed |
| US-4248721-A | MIXTURE OF CARBOXYLIC PENTAERYTHRITOL ESTER, PHENYL NAPHTHYLAMINE, DIPHENYLAMINE, POLYHYDROXYANTHRAQUINONE, PHOSPHATE ESTER, THIADIAZOLE DERIVATIVE | TEXACO INC. (US) | 1981-02-03 | — | — | US | claimed |
| US-4188298-A | ACYCLIC ESTER, ARYLAMINES, SULFIDES AND ARYL PHOSPHATES, OXIDATIVE STABILITY | TEXACO INC. (US) | 1980-02-12 | — | — | US | claimed |
| US-4179386-A | ALIPHATIC ESTER OIL, ARYL PHOSPHATE, POLYHYDROXYANTHRAQUINONE, DIALKYL SULFIDE, PHENYLNAPHTHYLAMINE OR DIALKYLDIPHENYLAMINE | TEXACO INC. (US) | 1979-12-18 | — | — | US | claimed |
| US-4157970-A | ALIPHATIC ESTER, A PHENYL NAPHTHYLAMINE, A PHOSPHATE ESTER, A POLYHYDROXY ANTHRAQUINONE, AND AN ALKYL MERCAPTO ACID ESTER | TEXACO INC. (US) | 1979-06-12 | — | — | US | claimed |
| US-4157971-A | ALIPHATIC ESTER, PHENYL NAPHTHYLAMINES, PHOSPHATE ESTER, POLYHYDROXY ANTHRAQUINONE, ALKYL THIOACID ESTER | TEXACO INC. (US) | 1979-06-12 | — | — | US | claimed |
| US-4119551-A | OXIDATION RESISTANCE, NAPHTHYLPHENYLAMINES AND DIPHENYLAMINES, POLYHYDROXYANTHRAQUINONE, PHOSPHATE ESTER, BIS/DIALKYLTHIOCARBAMYL) SULFIDE | TEXACO INC. (US) | 1978-10-10 | — | — | US | claimed |
| US-4002654-A | Process for the preparation of dihydroxyanthraquinones | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-11 | — | — | US | claimed |
| US-3977953-A | PHOTOSENSITIZED OXIDATION OF LUPULONES | ATLANTIC RESEARCH INSTITUTE LTD. (BA) | 1976-08-31 | — | — | US | claimed |