Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 9/20 | 0.40 |
| ▸ | ACACA | Q13085 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20214798 | 1.00 | CAMKK1 (0.45) | CAMKK1CAMKK2PIK3CDACACBACACA | |
| SCHEMBL20186464 | 0.90 | CAMKK1 (0.45) | CAMKK1CAMKK2PIK3CDACACBACACA | |
| SCHEMBL20186469 | 0.90 | CAMKK1 (0.45) | CAMKK1CAMKK2PIK3CDACACBACACA | |
| SCHEMBL20225403 | 0.86 | PIK3CD (0.49) | CAMKK1CAMKK2PIK3CDACACBACACA | |
| SCHEMBL20186565 | 0.79 | CAMKK1 (0.46) | CAMKK1CAMKK2PIK3CDMAPTSMN1; SMN2 | |
| SCHEMBL20186158 | 0.79 | CAMKK1 (0.46) | CAMKK1CAMKK2PIK3CDMAPTSMN1; SMN2 | |
| SCHEMBL20186162 | 0.79 | CAMKK1 (0.46) | CAMKK1CAMKK2PIK3CDMAPTSMN1; SMN2 | |
| SCHEMBL20186619 | 0.78 | CAMK2D (0.51) | CAMK2DKCNH2 | |
| SCHEMBL20186622 | 0.78 | CAMK2D (0.51) | CAMK2DKCNH2 | |
| SCHEMBL20186664 | 0.77 | CAMK2D (0.49) | CAMKK1CAMKK2PIK3CDACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548495-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018102384-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-06-07 | — | — | WO | disclosed |