Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 6/20 | 0.55 |
| ▸ | AXL | P30530 | 4/20 | 0.49 |
| ▸ | MERTK | Q12866 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 10/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20216622 | 0.86 | MET (0.51) | METAXLMERTKKDRIGF1R | |
| SCHEMBL371684 | 0.83 | MET (0.72) | METAXLMERTKKDRIGF1R | |
| SCHEMBL372754 | 0.79 | MET (0.70) | METAXLMERTKKDRIGF1R | |
| SCHEMBL371760 | 0.79 | KDR (0.67) | METAXLMERTKKDRPDGFRA | |
| SCHEMBL371630 | 0.77 | MET (0.83) | METAXLMERTKKDRIGF1R | |
| SCHEMBL30314058 | 0.77 | MET (0.83) | METAXLMERTKKDRIGF1R | |
| SCHEMBL4993698 | 0.75 | MET (0.68) | METAXLMERTKKDRIGF1R | |
| SCHEMBL409601 | 0.75 | MET (0.68) | METAXLMERTKKDRIGF1R | |
| SCHEMBL1893668 | 0.74 | PDGFRA (0.77) | METKDRIGF1RPDGFRAKIT | |
| SCHEMBL1890654 | 0.74 | PDGFRA (0.79) | METAXLMERTKKDRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |